Peptide-protein interactions play a critical role in the protein-protein interaction network with significant involvement in signal transduction and regulation. Many of these interactions are promising candidates as new leads for drug targets. However,
- Peptides often lack a distinct fold
- In many cases there is no data regarding the peptide binding site and/or the peptide backbone conformation.
- Structure-based modeling of these interactions is very challenging.
Using a ligand-based approach, SAFAN-ISPPEPT overcomes these challenges, to predict protein:peptides binding affinity quantitatively.